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Companies / Healthcare / Heartflow, Inc.
HTFL

Heartflow, Inc.

HealthcareSurgical & Medical Instruments
Ticker HTFLSAN FRANCISCO, CAFiscal year ends DecemberBook value per share $3.25Diluted shares 86.0M

Heartflow, Inc. (Nasdaq: FLOW) operates as a software and artificial intelligence company focused on transforming the diagnosis and management of coronary artery disease, a leading cause of death worldwide. The company's website is www.heartflow.com. From the company’s description.

Fiscal year 2025 · ends 12-31The amber dot is the latest twelve months, to 2026-06-30
Sales & profitability
$176.03M
Last 12 mo $212.07M
-36.39%
Last 12 mo -37.84%
$-116.79M
Last 12 mo $-118.37M
-38.85%
Last 12 mo -42.32%
Cash & financing
$-54.02M
Last 12 mo $-52.23M
$-59.05M
Last 12 mo $-59.18M
—
36.9M
Last 12 mo 86.0M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What Heartflow, Inc. does

In the company’s own words

Heartflow, Inc. (Nasdaq: FLOW) operates as a software and artificial intelligence company focused on transforming the diagnosis and management of coronary artery disease, a leading cause of death worldwide. The company's website is www.heartflow.com.

The company provides the Heartflow Platform, an AI-powered diagnostic solution that enhances coronary computed tomography angiography (CCTA) imaging by applying advanced computational fluid dynamics and deep learning algorithms to create personalized three-dimensional models of patients' hearts. This technology delivers actionable insights on blood flow, stenosis, plaque volume, and plaque composition, enabling more accurate non-invasive diagnosis compared to traditional imaging methods.

Heartflow's product portfolio consists of three commercially available offerings and one product expected to launch in the second quarter of 2026. Heartflow FFRCT Analysis, the company's flagship product, represents 98 percent of total revenue and calculates blood flow to identify clinically significant coronary artery disease. Heartflow RoadMap Analysis provides anatomical visualization to improve CCTA interpretation efficiency and consistency. Heartflow Plaque Analysis automatically assesses coronary plaque characteristics and volumes to optimize medical treatment strategies. The forthcoming Heartflow PCI Navigator will provide pre-procedure assessment for interventional cardiologists.

As of December 31, 2025, the Heartflow Platform had been used to assess coronary artery disease in more than 600,000 patients, including 219,000 in 2025 alone. The company operates more than 1,465 accounts across the United States. The platform has been validated through over 200 clinical studies involving more than 365,000 patients, with results published in over 600 peer-reviewed publications.

Heartflow generates revenue on a pay-per-click basis, with customers billed each time physicians access Heartflow FFRCT Analysis or Heartflow Plaque Analysis. Both products have received FDA clearance and established Category I Current Procedural Terminology codes, with reimbursement coverage representing approximately 99 percent of covered lives for FFRCT Analysis and 75 percent for Plaque Analysis. The company employs a direct sales organization combining Territory Sales Managers focused on new account acquisition with Territory Account Managers driving utilization expansion at existing accounts.

Company details
Sector
Healthcare
Industry
Surgical & Medical Instruments
Headquarters
SAN FRANCISCO, CA
Fiscal year end
December
CIK
1464521
SIC
3841

Financial performance, year by year

Fiscal 2025–2025 · USD
$-151.42M$-52.28M$46.85M$145.98M$245.12M2025Last 12 moLast 12 monthsLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns Heartflow, Inc. — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

216
funds hold it
0 of 35
superinvestors hold it
$984.11M
held by funds, at market
38.1%
of shares held by funds

Largest fund holders · Heartflow, Inc.’s weight in each

VANGUARD HEALTH CARE FUND
VGHCX · VANGUARD SPECIALIZED FUNDS
0.46%of fund net assets
VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.00%of fund net assets
iShares Russell 2000 ETF
IWM · iShares Trust
0.07%of fund net assets
VANGUARD SMALL-CAP INDEX FUND
VB · VANGUARD INDEX FUNDS
0.03%of fund net assets
BARON DISCOVERY FUND
BDFFX · BARON INVESTMENT FUNDS TRUST (f/k/a BARON ASSET FUND)
2.57%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Could not be determined for this company: bond issues.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

Put this business in context.

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