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Companies / Health Care / Palvella Therapeutics, Inc.
PVLA

Palvella Therapeutics, Inc.

Health CarePharmaceutical Preparations
Ticker PVLAWAYNE, PAFiscal year ends DecemberBook value per share $14.14Diluted shares 14.0M

Palvella Therapeutics, Inc. (Nasdaq: PVLA) is a clinical-stage biopharmaceutical company developing therapies for serious, rare skin diseases and vascular malformations, with plans to commercialize products if approved. Its proprietary QTORIN platform is designed to deliver topical drugs into the deeper layers of skin… From the company’s description.

In fiscal 2025, Palvella Therapeutics, Inc. reported a net loss of $41.72M. Operations used $25.01M in cash.

Fiscal year 2025 · ends 12-31Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-09-30
Sales & profitability
—
0.00%FY2025
$-41.72MFY2025
−139.3% year over year
Last 12 mo $-74.99M
-149.07%FY2025
−121.2 percentage points
Last 12 mo -37.89%
Cash & financing
$-25.01MFY2025
−130.7% year over year
Last 12 mo $-43.06M
$-25.01MFY2025
−130.7% year over year
Last 12 mo $-43.06M
—
11.3MFY2025
+405.5% year over year
Last 12 mo 14.0M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What Palvella Therapeutics, Inc. does

In the company’s own words

Palvella Therapeutics, Inc. (Nasdaq: PVLA) is a clinical-stage biopharmaceutical company developing therapies for serious, rare skin diseases and vascular malformations, with plans to commercialize products if approved. Its proprietary QTORIN platform is designed to deliver topical drugs into the deeper layers of skin with limited systemic absorption. The lead candidate, QTORIN rapamycin, is in clinical development for microcystic lymphatic malformations and cutaneous venous malformations, with development also extending to clinically significant angiokeratomas. QTORIN pitavastatin is being developed for disseminated superficial actinic porokeratosis, and the company has additional preclinical programs. Palvella serves patients with these conditions and the clinicians who treat them; its proposed U.S. commercialization approach centers on specialty sales targeting vascular anomaly centers, dermatologists and other relevant specialists. The company’s business became primarily that of Legacy Palvella following its December 2024 merger with Pieris Pharmaceuticals, which then adopted the Palvella name. Its website is www.palvellatherapeutics.com.

Company details
Sector
Health Care
Industry (SIC)
Pharmaceutical Preparations
Headquarters
WAYNE, PA
Fiscal year end
December
CIK
1583648
SIC
2834

Financial performance, year by year

Fiscal 2014–2025 · USD
$-87.12M$-50.74M$-14.36M$22.02M$58.41M201420152016201720182019202020212022202320242025Last 12 moLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns Palvella Therapeutics, Inc. — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

183
funds hold it
0 of 35
superinvestors hold it
$651.07M
held by funds, at market
31.4%
of shares held by funds

Largest fund holders · Palvella Therapeutics, Inc.’s weight in each

0.58%of fund net assets
VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.00%of fund net assets
iShares Russell 2000 ETF
IWM · iShares Trust
0.05%of fund net assets
Federated Hermes Kaufmann Fund
KAUAX · Federated Hermes Equity Funds
—of fund net assets
Eventide Healthcare & Life Sciences Fund
ETAHX · MUTUAL FUND SERIES TRUST
1.98%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

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