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Companies / Health Care / Twist Bioscience Corp
TWST

Twist Bioscience Corp

Health CareBiological Products
Ticker TWSTSOUTH SAN FRANCISCO, CAFiscal year ends SeptemberBook value per share $7.22Diluted shares 61.7M

Twist Bioscience Corporation (Nasdaq: TWST) develops and manufactures synthetic DNA and related products using a proprietary platform that writes DNA on silicon chips. Its offerings include synthetic genes and gene fragments, oligonucleotide pools, RNA and proteins, next-generation sequencing (NGS) sample-preparation… From the company’s description.

In fiscal 2025, Twist Bioscience Corp reported revenue of $376.57M, up 20.3% from fiscal 2024, and a net loss of $77.67M. Its operating margin was −36.2%, and operations used $47.63M in cash. Over the twelve months to Jun 30, 2026, revenue was $431.80M.

Fiscal year 2025 · ends 09-30Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-06-30
Sales & profitability
$376.57MFY2025
+20.3% year over year
Last 12 mo $431.80M
-36.18%FY2025
+34.4 percentage points
Last 12 mo -33.58%
$-77.67MFY2025
+62.8% year over year
Last 12 mo $-136.72M
-16.42%FY2025
+18.3 percentage points
Last 12 mo -30.67%
Cash & financing
$-47.63MFY2025
+25.7% year over year
Last 12 mo $-53.07M
$-75.63MFY2025
−9.3% year over year
Last 12 mo $-98.12M
0.03FY2025
Last 12 mo 0.03
59.8MFY2025
+3.1% year over year
Last 12 mo 61.7M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What Twist Bioscience Corp does

In the company’s own words

Twist Bioscience Corporation (Nasdaq: TWST) develops and manufactures synthetic DNA and related products using a proprietary platform that writes DNA on silicon chips. Its offerings include synthetic genes and gene fragments, oligonucleotide pools, RNA and proteins, next-generation sequencing (NGS) sample-preparation tools, and biopharma services for antibody discovery, optimization and development. Customers include biotechnology and pharmaceutical companies, diagnostic companies, hospitals, research institutions, agricultural and industrial businesses, and academic laboratories. The company serves healthcare, chemicals and materials, academic research, and food and agriculture markets, and reports its business through synthetic biology products, NGS tools, and biopharma services. Its products support applications ranging from drug discovery and disease testing to crop research and development of chemicals and materials. In fiscal 2025, Twist served more than 3,800 customers and generated $376.6 million in revenue; it had 979 employees as of September 30, 2025. Its website is www.twistbioscience.com.

Company details
Sector
Health Care
Industry (SIC)
Biological Products
Headquarters
SOUTH SAN FRANCISCO, CA
Fiscal year end
September
CIK
1581280
SIC
2836

Financial performance, year by year

Fiscal 2019–2025 · USD
$-282.83M$-87.93M$106.97M$301.87M$496.76M2019202020212022202320242025Last 12 moLast 12 monthsLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns Twist Bioscience Corp — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

330
funds hold it
1 of 35
superinvestors hold it
$2.86B
held by funds, at market
54.2%
of shares held by funds

Superinvestors in Twist Bioscience Corp · what they did last quarter

Polen CapitalINCREASED +130.1%
Polen Capital Management
<0.1%of 13F portfolio

Share of each manager’s reported 13F portfolio. Change is in shares held, since the previous quarter.

Largest fund holders · Twist Bioscience Corp’s weight in each

ARK Innovation ETF
ARKK · ARK ETF Trust
—of fund net assets
VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.01%of fund net assets
iShares Russell 2000 ETF
IWM · iShares Trust
0.20%of fund net assets
1.41%of fund net assets
VANGUARD SMALL-CAP INDEX FUND
VB · VANGUARD INDEX FUNDS
0.07%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Fund ownership is a subset of institutional 13F ownership — the two describe overlapping populations and must not be added together.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

Put this business in context.

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  • “How do Twist Bioscience Corp and its peers compare on margins and cash generation over ten years?”
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