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Companies / Health Care / Twist Bioscience Corp
TWST

Twist Bioscience Corp

Health CareBiological Products
Ticker TWSTSOUTH SAN FRANCISCO, CAFiscal year ends SeptemberBook value per share $7.22Diluted shares 61.7M

Twist Bioscience Corporation (NASDAQ: TWST) operates as a leading provider of synthetic DNA and related life sciences solutions, serving customers across research, development, and commercial applications globally. The company's website is www.twistbioscience.com. From the company’s description.

Fiscal year 2025 · ends 09-30Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-06-30
Sales & profitability
$376.57M
+20.3% year over year
Last 12 mo $431.80M
-36.18%
+34.4 percentage points
Last 12 mo -33.58%
$-77.67M
+62.8% year over year
Last 12 mo $-136.72M
-16.42%
+18.3 percentage points
Last 12 mo -30.67%
Cash & financing
$-47.63M
+25.7% year over year
Last 12 mo $-53.07M
$-75.63M
−9.3% year over year
Last 12 mo $-98.12M
0.03
Last 12 mo 0.03
59.8M
+3.1% year over year
Last 12 mo 61.7M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What Twist Bioscience Corp does

In the company’s own words

Twist Bioscience Corporation (NASDAQ: TWST) operates as a leading provider of synthetic DNA and related life sciences solutions, serving customers across research, development, and commercial applications globally. The company's website is www.twistbioscience.com.

The company has developed a disruptive DNA synthesis platform that industrializes the engineering of biology through proprietary silicon-chip-based technology. Rather than using traditional plate-based synthesis methods, Twist manufactures synthetic DNA by writing over one million oligonucleotide pieces directly onto silicon chips approximately the size of a large mobile phone, reducing chemical usage by an estimated 99.8% compared to conventional approaches. This core platform combines silicon-based DNA writing technology with proprietary software, scalable commercial infrastructure, and an e-commerce platform to deliver high-quality, precise, and cost-effective DNA synthesis at significant manufacturing throughput.

Twist generates revenue through two primary product lines and a services offering. The synthetic biology segment includes synthetic genes, gene fragments, oligonucleotide pools, IgG proteins, and synthetic controls. The next-generation sequencing tools segment provides library preparation kits, exome kits, fixed and custom panels, and workflow solutions for diagnostic applications. The company also offers comprehensive biopharma services for antibody discovery, optimization, and development, including in vivo, in vitro, and in silico discovery platforms. In fiscal year 2025, the company reported revenue of $376.6 million, with healthcare representing $215.1 million, chemicals and materials $93.2 million, academic research $65.9 million, and food and agriculture $2.4 million.

The company serves more than 3,800 customers across academic institutions, biopharmaceutical companies, diagnostic firms, and industrial biotechnology organizations. As of September 30, 2025, Twist employed 979 people across its operations, including 412 in manufacturing and operations, 278 in sales and marketing, 198 in general and administrative functions, and 91 in research and development. The company operates manufacturing facilities in South San Francisco, California and Wilsonville, Oregon, and maintains a global commercial presence through direct sales personnel, e-commerce platforms, and commercial consultants in Europe and Asia.

Company details
Sector
Health Care
Industry (SIC)
Biological Products
Headquarters
SOUTH SAN FRANCISCO, CA
Fiscal year end
September
CIK
1581280
SIC
2836

Financial performance, year by year

Fiscal 2019–2025 · USD
$-282.83M$-87.93M$106.97M$301.87M$496.76M2019202020212022202320242025Last 12 moLast 12 monthsLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns Twist Bioscience Corp — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

330
funds hold it
1 of 35
superinvestors hold it
$2.86B
held by funds, at market
54.2%
of shares held by funds

Superinvestors in Twist Bioscience Corp · what they did last quarter

Polen CapitalINCREASED +130.1%
Polen Capital Management
<0.1%of 13F portfolio

Share of each manager’s reported 13F portfolio. Change is in shares held, since the previous quarter.

Largest fund holders · Twist Bioscience Corp’s weight in each

ARK Innovation ETF
ARKK · ARK ETF Trust
—of fund net assets
VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.01%of fund net assets
iShares Russell 2000 ETF
IWM · iShares Trust
0.20%of fund net assets
1.41%of fund net assets
VANGUARD SMALL-CAP INDEX FUND
VB · VANGUARD INDEX FUNDS
0.07%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Fund ownership is a subset of institutional 13F ownership — the two describe overlapping populations and must not be added together.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

Put this business in context.

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  • “How do Twist Bioscience Corp and its peers compare on margins and cash generation over ten years?”
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