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Companies / Health Care / 4D Molecular Therapeutics, Inc.
FDMT

4D Molecular Therapeutics, Inc.

Health CareBiological Products
Ticker FDMTEMERYVILLE, CAFiscal year ends DecemberBook value per share $5.89Diluted shares 69.2M

4D Molecular Therapeutics, Inc. (Nasdaq: FDMT) is a clinical-stage biotechnology company developing genetic medicines using customized adeno-associated virus vectors discovered through its Therapeutic Vector Evolution platform. Its pipeline targets retinal and lung diseases, with 4D-150, a gene therapy candidate for… From the company’s description.

Over the twelve months to Jun 30, 2026, 4D Molecular Therapeutics, Inc. reported revenue of $92.01M, up 278712.1% from a year earlier, and a net loss of $179.18M. Its operating margin was −214.2%, and operations used $156.07M in cash. In fiscal 2025, it reported revenue of $85.21M, up 230194.6% from fiscal 2024, and a net loss of $140.11M.

Fiscal year 2025 · ends 12-31Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-06-30
Sales & profitability
$85.21MFY2025
+230194.6% year over year
Last 12 mo $92.01M
-187.24%FY2025
+507491.1 percentage points
Last 12 mo -214.24%
$-140.11MFY2025
+12.9% year over year
Last 12 mo $-179.18M
-27.71%FY2025
+3.8 percentage points
Last 12 mo -43.95%
Cash & financing
$-109.08MFY2025
+18.9% year over year
Last 12 mo $-156.07M
$-109.62MFY2025
+20.8% year over year
Last 12 mo $-156.18M
—
Last 12 mo 0.05
57.9MFY2025
+7.4% year over year
Last 12 mo 69.2M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What 4D Molecular Therapeutics, Inc. does

In the company’s own words

4D Molecular Therapeutics, Inc. (Nasdaq: FDMT) is a clinical-stage biotechnology company developing genetic medicines using customized adeno-associated virus vectors discovered through its Therapeutic Vector Evolution platform. Its pipeline targets retinal and lung diseases, with 4D-150, a gene therapy candidate for wet age-related macular degeneration and diabetic macular edema, in Phase 3 development for wet AMD; other programs include 4D-175 for geographic atrophy, 4D-710 for cystic fibrosis, and 4D-725 for alpha-1 antitrypsin deficiency. The company’s vectors are designed for tissue-specific delivery, including intravitreal injection for retinal diseases and aerosol administration for lung conditions. It develops and manufactures candidates for clinical trials in-house, supplements capacity through contract manufacturers, and expects to rely on external manufacturing for potential commercial supply. Founded in 2013, the company has developed vector libraries containing approximately one billion synthetic capsid sequences. Its single reported business is the discovery and development of genetic medicines; it reports no commercial product revenue. The company employs its platform across discovery, preclinical research, and clinical programs. Its website is https://4dmoleculartherapeutics.com.

Company details
Sector
Health Care
Industry (SIC)
Biological Products
Headquarters
EMERYVILLE, CA
Fiscal year end
December
CIK
1650648
SIC
2836

Financial performance, year by year

Fiscal 2020–2025 · USD
$-206.29M$-124.94M$-43.58M$37.77M$119.13M202020212022202320242025Last 12 moLast 12 monthsLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns 4D Molecular Therapeutics, Inc. — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

170
funds hold it
0 of 35
superinvestors hold it
$165.68M
held by funds, at market
24.8%
of shares held by funds

Largest fund holders · 4D Molecular Therapeutics, Inc.’s weight in each

0.20%of fund net assets
VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.00%of fund net assets
iShares Russell 2000 ETF
IWM · iShares Trust
0.02%of fund net assets
Janus Henderson Global Life Sciences Fund
JAGLX · Janus Investment Fund
0.18%of fund net assets
T. Rowe Price Small-Cap Stock Fund, Inc.
OTCFX · T. ROWE PRICE SMALL-CAP STOCK FUND, INC.
0.10%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Could not be determined for this company: bond issues.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

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