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Companies / Health Care / Aclaris Therapeutics, Inc.
ACRS

Aclaris Therapeutics, Inc.

Health CarePharmaceutical Preparations
Ticker ACRSWAYNE, PAFiscal year ends DecemberBook value per share $1.19Diluted shares 140.4M

Aclaris Therapeutics, Inc. (Nasdaq: ACRS) is a clinical-stage biopharmaceutical company that discovers and develops small-molecule and biologic candidates for immuno-inflammatory diseases. Its pipeline includes bosakitug, an anti-TSLP antibody; ATI-052, a bispecific antibody targeting TSLP and IL-4 receptor alpha; and… From the company’s description.

Over the twelve months to Sep 30, 2026, Aclaris Therapeutics, Inc. reported revenue of $6.40M, down 59.3% from a year earlier, and a net loss of $79.63M. Operations used $75.21M in cash. In fiscal 2025, it reported revenue of $7.83M, down 58.2% from fiscal 2024, and a net loss of $64.92M.

Fiscal year 2025 · ends 12-31Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-09-30
Sales & profitability
$7.83MFY2025
−58.2% year over year
Last 12 mo $6.40M
-975.91%FY2025
−217.7 percentage points
Last 12 mo -1413.97%
$-64.92MFY2025
+50.8% year over year
Last 12 mo $-79.63M
-62.98%FY2025
+21.9 percentage points
Last 12 mo -47.74%
Cash & financing
$-47.11MFY2025
−134.7% year over year
Last 12 mo $-75.21M
$-47.22MFY2025
−133.8% year over year
Last 12 mo $-75.31M
—
122.6MFY2025
+58.6% year over year
Last 12 mo 140.4M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What Aclaris Therapeutics, Inc. does

In the company’s own words

Aclaris Therapeutics, Inc. (Nasdaq: ACRS) is a clinical-stage biopharmaceutical company that discovers and develops small-molecule and biologic candidates for immuno-inflammatory diseases. Its pipeline includes bosakitug, an anti-TSLP antibody; ATI-052, a bispecific antibody targeting TSLP and IL-4 receptor alpha; and the oral kinase inhibitors ATI-2138 and ATI-9494, which target ITK pathways. The company also develops lepzacitinib, a topical JAK 1/3 inhibitor, and uses its proprietary KINect platform for kinase drug discovery. Its programs address conditions including atopic dermatitis, asthma, and other inflammatory and autoimmune diseases; candidates are investigational, and Aclaris seeks third-party partners to help develop, secure approval for, or commercialize them. Aclaris licenses bosakitug and ATI-052 from Biosion for territories outside Greater China. It acquired lepzacitinib and ATI-2138 through its 2017 acquisition of Confluence. Aclaris reports a single operating and reportable segment and had no product sales in 2025. Its website is https://www.aclaristx.com/.

Company details
Sector
Health Care
Industry (SIC)
Pharmaceutical Preparations
Headquarters
WAYNE, PA
Fiscal year end
December
CIK
1557746
SIC
2834

Financial performance, year by year

Fiscal 2015–2025 · USD
$-180.61M$-122.83M$-65.05M$-7.27M$50.51M20152016201720182019202020212022202320242025Last 12 moLast 12 monthsLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns Aclaris Therapeutics, Inc. — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

130
funds hold it
0 of 35
superinvestors hold it
$94.29M
held by funds, at market
11.7%
of shares held by funds

Largest fund holders · Aclaris Therapeutics, Inc.’s weight in each

VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.00%of fund net assets
iShares Russell 2000 ETF
IWM · iShares Trust
0.02%of fund net assets
VANGUARD EXTENDED MARKET INDEX FUND
VXF · VANGUARD INDEX FUNDS
0.01%of fund net assets
0.03%of fund net assets
iShares Biotechnology ETF
IBB · iShares Trust
0.05%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

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