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Companies / Health Care / Alector, Inc.
ALEC

Alector, Inc.

Health CareBiological Products
Ticker ALECSOUTH SAN FRANCISCO, CAFiscal year ends DecemberBook value per share $1.04Diluted shares 112.0M

Alector, Inc. (Nasdaq: ALEC) is a clinical-stage biotechnology company developing therapies for neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and Lewy body dementia. Its programs aim to remove pathogenic proteins, replace deficient proteins or restore cellular function, using… From the company’s description.

Over the twelve months to Sep 30, 2026, Alector, Inc. reported revenue of $173.47M, up 151.2% from a year earlier, and net income of $41.41M. Its operating margin was 20.2%, and operations used $149.88M in cash. In fiscal 2025, it reported revenue of $21.05M, down 79.1% from fiscal 2024, and a net loss of $142.93M.

Fiscal year 2025 · ends 12-31Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-09-30
Sales & profitability
$21.05MFY2025
−79.1% year over year
Last 12 mo $173.47M
-741.30%FY2025
−597.1 percentage points
Last 12 mo 20.16%
$-142.93MFY2025
−20.1% year over year
Last 12 mo $41.41M
-466.34%FY2025
−372.5 percentage points
Last 12 mo 35.53%
Cash & financing
$-184.03MFY2025
+20.0% year over year
Last 12 mo $-149.88M
$-184.07MFY2025
+20.4% year over year
Last 12 mo $-150.02M
0.32FY2025
Was 0.07× a year earlier
Last 12 mo 0.00
103.0MFY2025
+6.6% year over year
Last 12 mo 112.0M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What Alector, Inc. does

In the company’s own words

Alector, Inc. (Nasdaq: ALEC) is a clinical-stage biotechnology company developing therapies for neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and Lewy body dementia. Its programs aim to remove pathogenic proteins, replace deficient proteins or restore cellular function, using antibodies, enzymes and small interfering RNA (siRNA). Its lead clinical candidate, nivisnebart, is being co-developed with GlaxoSmithKline to elevate progranulin levels and is under evaluation in a Phase 2 trial for early Alzheimer’s disease. Alector’s proprietary Alector Brain Carrier (ABC) platform is designed to transport therapies across the blood-brain barrier; it supports preclinical programs including an anti-amyloid beta antibody, a GCase enzyme replacement therapy and siRNA candidates targeting tau, alpha-synuclein and NLRP3. The company’s portfolio is focused on research and development, with no approved drugs or commercial product sales. Its collaboration with GSK covers the development and potential commercialization of progranulin-elevating antibodies, while Alector retains wholly owned preclinical and research programs. Its website is https://www.alector.com/.

Company details
Sector
Health Care
Industry (SIC)
Biological Products
Headquarters
SOUTH SAN FRANCISCO, CA
Fiscal year end
December
CIK
1653087
SIC
2836

Financial performance, year by year

Fiscal 2019–2025 · USD
$-229.96M$-110.77M$8.43M$127.62M$246.82M2019202020212022202320242025Last 12 moLast 12 monthsLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns Alector, Inc. — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

127
funds hold it
0 of 35
superinvestors hold it
$37.30M
held by funds, at market
11.9%
of shares held by funds

Largest fund holders · Alector, Inc.’s weight in each

VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.00%of fund net assets
iShares Russell 2000 ETF
IWM · iShares Trust
0.01%of fund net assets
Select Biotechnology Portfolio
FBIOX · Fidelity Select Portfolios
—of fund net assets
Fidelity Small Cap Index Fund
FSSNX · Fidelity Salem Street Trust
—of fund net assets
VANGUARD EXTENDED MARKET INDEX FUND
VXF · VANGUARD INDEX FUNDS
0.00%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

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