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Companies / Health Care / Annovis Bio, Inc.
ANVS

Annovis Bio, Inc.

Health CarePharmaceutical Preparations
Ticker ANVSMALVERN, PAFiscal year ends DecemberBook value per share $-0.13Diluted shares 32.7M

Annovis Bio, Inc. (NYSE: ANVS) is a clinical-stage biotechnology company developing treatments for neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. Its lead candidate, buntanetap, is an oral small molecule designed to reduce the production of multiple neurotoxic proteins; the company… From the company’s description.

In fiscal 2025, Annovis Bio, Inc. reported a net loss of $28.85M. Operations used $25.62M in cash.

Fiscal year 2025 · ends 12-31Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-06-30
Sales & profitability
—
0.00%FY2025
$-28.85MFY2025
−17.3% year over year
Last 12 mo $-49.52M
-171.50%FY2025
+92.8 percentage points
Last 12 mo 1163.97%
Cash & financing
$-25.62MFY2025
−17.0% year over year
Last 12 mo $-43.34M
$-25.62MFY2025
−17.0% year over year
Last 12 mo $-43.34M
—
20.6MFY2025
+68.0% year over year
Last 12 mo 32.7M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What Annovis Bio, Inc. does

In the company’s own words

Annovis Bio, Inc. (NYSE: ANVS) is a clinical-stage biotechnology company developing treatments for neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. Its lead candidate, buntanetap, is an oral small molecule designed to reduce the production of multiple neurotoxic proteins; the company is testing it in a Phase 3 Alzheimer’s study and a long-term Parkinson’s disease study, and is planning a program for Parkinson’s disease dementia. Annovis also develops ANVS405, an intravenous candidate for acute brain injury, including traumatic brain injury and stroke, and ANVS301, an oral candidate for later-stage Alzheimer’s disease and dementia. The company’s research focuses on a platform intended to target several neurotoxic proteins and address nerve-cell function across multiple conditions. It reports that more than 1,200 people have received buntanetap in clinical studies. Annovis has no reportable operating segments described in its business overview.

Company details
Sector
Health Care
Industry (SIC)
Pharmaceutical Preparations
Headquarters
MALVERN, PA
Fiscal year end
December
CIK
1477845
SIC
2834

Financial performance, year by year

Fiscal 2020–2025 · USD
$-61.28M$-46.06M$-30.83M$-15.61M$-0.39M202020212022202320242025Last 12 moLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns Annovis Bio, Inc. — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

14
funds hold it
0 of 35
superinvestors hold it
$3.74M
held by funds, at market
4.7%
of shares held by funds

Largest fund holders · Annovis Bio, Inc.’s weight in each

VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.00%of fund net assets
VANGUARD EXTENDED MARKET INDEX FUND
VXF · VANGUARD INDEX FUNDS
0.00%of fund net assets
Fidelity Extended Market Index Fund
FSMAX · Fidelity Concord Street Trust
—of fund net assets
iShares Micro-Cap ETF
IWC · iShares Trust
0.01%of fund net assets
Fidelity Total Market Index Fund
FSKAX · Fidelity Concord Street Trust
—of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

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