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Companies / Health Care / aTYR PHARMA INC
ATYR

aTYR PHARMA INC

Health CareBiological Products
Ticker ATYRSAN DIEGO, CAFiscal year ends DecemberBook value per share $13.85Diluted shares 2.5M

aTyr Pharma, Inc. (Nasdaq: ATYR) is a clinical-stage biotechnology company developing biologic therapies for fibrosis and inflammation using a discovery platform based on extracellular biology of tRNA synthetases. Its lead candidate, efzofitimod, is in development for interstitial lung diseases, including pulmonary… From the company’s description.

Over the twelve months to Sep 30, 2026, aTYR PHARMA INC reported a net loss of $53.32M. Operations used $43.58M in cash. In fiscal 2025, it reported revenue of $0.19M, down 19.1% from fiscal 2024, and a net loss of $74.12M.

Fiscal year 2025 · ends 12-31Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-09-30
Sales & profitability
$0.19MFY2025
−19.1% year over year
Last 12 mo $0.00M
-40856.32%FY2025
−11956.7 percentage points
$-74.12MFY2025
−15.8% year over year
Last 12 mo $-53.32M
-109.84%FY2025
−18.4 percentage points
Last 12 mo -156.92%
Cash & financing
$-61.99MFY2025
+10.3% year over year
Last 12 mo $-43.58M
$-62.06MFY2025
+10.3% year over year
Last 12 mo $-43.86M
0.01FY2025
Was 0.02× a year earlier
Last 12 mo 0.01
93.0MFY2025
+25.2% year over year
Last 12 mo 2.5M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What aTYR PHARMA INC does

In the company’s own words

aTyr Pharma, Inc. (Nasdaq: ATYR) is a clinical-stage biotechnology company developing biologic therapies for fibrosis and inflammation using a discovery platform based on extracellular biology of tRNA synthetases. Its lead candidate, efzofitimod, is in development for interstitial lung diseases, including pulmonary sarcoidosis and systemic sclerosis-associated ILD; the company is also evaluating it in a Phase 2 study in SSc-ILD. Additional preclinical candidates include ATYR0101, a fusion protein being studied for fibrotic diseases, and ATYR0750, a candidate targeting FGFR4. The company’s research also uses a proprietary library of domains derived from all 20 tRNA synthetases to identify potential drug candidates. aTyr has an exclusive Japan development and commercialization agreement for efzofitimod with Kyorin Pharmaceutical, which funds activities there, while aTyr supplies drug product and supports development. The company is pre-commercial and reports its operations as a single business. Its website is https://www.atyrpharma.com.

Company details
Sector
Health Care
Industry (SIC)
Biological Products
Headquarters
SAN DIEGO, CA
Fiscal year end
December
CIK
1339970
SIC
2836

Financial performance, year by year

Fiscal 2015–2025 · USD
$-82.58M$-57.21M$-31.83M$-6.46M$18.91M20152016201720182019202020212022202320242025Last 12 moLast 12 monthsLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns aTYR PHARMA INC — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

54
funds hold it
0 of 35
superinvestors hold it
$16.17M
held by funds, at market

Largest fund holders · aTYR PHARMA INC’s weight in each

Federated Hermes Kaufmann Fund
KAUAX · Federated Hermes Equity Funds
—of fund net assets
Federated Hermes Kaufmann Small Cap Fund
FKASX · Federated Hermes Equity Funds
—of fund net assets
Fidelity Growth Company Fund
FDGRX · Fidelity Mt. Vernon Street Trust
—of fund net assets
VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.00%of fund net assets
Select Biotechnology Portfolio
FBIOX · Fidelity Select Portfolios
—of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

Put this business in context.

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