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Companies / Healthcare / BIOCRYST PHARMACEUTICALS INC
BCRX

BIOCRYST PHARMACEUTICALS INC

HealthcareBiological Products
Ticker BCRXDURHAM, NCFiscal year ends DecemberBook value per share $-1.83Diluted shares 248.4M

BioCryst Pharmaceuticals, Inc. (NASDAQ: BCRX) is a biotechnology company focused on discovering and developing novel small-molecule and protein therapeutics for rare diseases. The company operates through its primary business of drug development and commercialization, with a particular emphasis on complement-mediated… From the company’s description.

Fiscal year 2025 · ends 12-31Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-06-30
Sales & profitability
$874.84M
+94.1% year over year
Last 12 mo $940.61M
38.98%
+39.5 percentage points
Last 12 mo -33.29%
$263.86M
+396.9% year over year
Last 12 mo $-384.67M
-221.45%
−240.1 percentage points
Last 12 mo 84.68%
Cash & financing
$347.37M
+767.8% year over year
Last 12 mo $376.13M
$344.90M
+749.0% year over year
Last 12 mo $373.38M
-3.93
Was -1.68× a year earlier
Last 12 mo -1.81
218.6M
+5.7% year over year
Last 12 mo 248.4M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What BIOCRYST PHARMACEUTICALS INC does

In the company’s own words

BioCryst Pharmaceuticals, Inc. (NASDAQ: BCRX) is a biotechnology company focused on discovering and developing novel small-molecule and protein therapeutics for rare diseases. The company operates through its primary business of drug development and commercialization, with a particular emphasis on complement-mediated rare diseases and other therapeutic areas where unmet medical needs exist.

The company's pipeline includes both clinical-stage and commercial-stage programs targeting conditions such as paroxysmal nocturnal hemoglobinuria, C3 glomerulopathy, post-transplant complications, and other rare genetic and acquired disorders. BioCryst leverages its expertise in structure-based drug design and protein engineering to develop treatments that address the underlying causes of rare diseases rather than merely managing symptoms.

BioCryst's business model centers on the discovery, development, and commercialization of innovative therapeutics, with revenue generation from product sales, licensing agreements, and potential milestone payments from partnerships. The company maintains research and development facilities and operates commercial operations to support the launch and marketing of approved products. The organization maintains a global presence with operations across multiple jurisdictions to support its clinical development programs and commercial activities.

The company's competitive advantages include its proprietary drug discovery and development platform, expertise in complement biology and other disease mechanisms, and a focused pipeline strategy targeting areas with significant unmet medical needs in rare disease populations. BioCryst's approach emphasizes precision medicine and mechanism-based therapeutics, positioning it within the specialized biotechnology sector serving patients with rare genetic and acquired disorders.

The company's financial structure reflects typical biotechnology industry characteristics, with significant research and development investments supporting its pipeline advancement and commercialization efforts. BioCryst maintains strategic partnerships and collaborations to enhance its development capabilities and expand its market reach. The organization is committed to advancing its pipeline programs through clinical development stages toward regulatory approval and commercialization.

BioCryst's website is located at www.biocryst.com.

Company details
Sector
Healthcare
Industry
Biological Products
Headquarters
DURHAM, NC
Fiscal year end
December
CIK
882796
SIC
2836

Financial performance, year by year

Fiscal 2013–2025 · USD
$-517.20M$-119.62M$277.97M$675.56M$1.07B2013201420152016201720182019202020212022202320242025Last 12 moLast 12 monthsLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns BIOCRYST PHARMACEUTICALS INC — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

227
funds hold it
0 of 35
superinvestors hold it
$733.01M
held by funds, at market
29.5%
of shares held by funds

Largest fund holders · BIOCRYST PHARMACEUTICALS INC’s weight in each

0.89%of fund net assets
VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.00%of fund net assets
iShares Russell 2000 ETF
IWM · iShares Trust
0.07%of fund net assets
VANGUARD SMALL-CAP INDEX FUND
VB · VANGUARD INDEX FUNDS
0.02%of fund net assets
VANGUARD EXTENDED MARKET INDEX FUND
VXF · VANGUARD INDEX FUNDS
0.03%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

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