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Companies / Health Care / Charles River Laboratories
CRL

Charles River Laboratories

Health CareProfessional ServicesS&P 500
Ticker CRLWILMINGTON, MAFiscal year ends DecemberBook value per share $58.57Diluted shares 48.5M

Charles River Laboratories International, Inc. (NYSE: CRL) provides non-clinical drug research and development services, research models, and products and services that support biopharmaceutical manufacturing and quality testing. Its customers include pharmaceutical and biotechnology companies, chemical and… From the company’s description.

In fiscal 2025, Charles River Laboratories reported revenue of $4.02B, down 0.9% from fiscal 2024, and a net loss of $142.16M. Its operating margin was 0.6%, and operations generated $737.65M in cash. Over the twelve months to Jun 27, 2026, revenue was $4.00B.

Fiscal year 2025 · ends 12-27Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-06-27
Sales & profitability
$4.02BFY2025
−0.9% year over year
Last 12 mo $4.00B
0.63%FY2025
−5 percentage points
Last 12 mo 2.25%
$-142.16MFY2025
−662.1% year over year
Last 12 mo $-236.30M
-1.58%FY2025
−3.9 percentage points
Last 12 mo -8.40%
Cash & financing
$737.65MFY2025
+0.4% year over year
Last 12 mo $582.15M
$518.49MFY2025
+3.4% year over year
Last 12 mo $370.60M
0.68FY2025
Was 0.65× a year earlier
Last 12 mo 0.92
49.6MFY2025
−4.0% year over year
Last 12 mo 48.5M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What Charles River Laboratories does

In the company’s own words

Charles River Laboratories International, Inc. (NYSE: CRL) provides non-clinical drug research and development services, research models, and products and services that support biopharmaceutical manufacturing and quality testing. Its customers include pharmaceutical and biotechnology companies, chemical and consumer-product manufacturers, contract research organizations, academic institutions, hospitals, and government agencies. The company operates three reportable segments: Research Models and Services, which supplies purpose-bred research models and related services and represented 21.1% of 2025 revenue; Discovery and Safety Assessment, which provides drug discovery, bioanalytical, and regulatory safety testing services and represented 59.8%; and Manufacturing Solutions, which provides microbial testing, biologics testing, and contract development and manufacturing and represented 19.1%. Its brands include Endosafe, Celsis, and Accugenix in microbial testing, and CRADL research facilities. Charles River began operating in 1947 and has since developed a broader portfolio spanning early drug research through manufacturing support. In 2025, revenue was $4.0 billion, and the company operated at more than 120 sites in over 20 countries. Its website is www.criver.com.

Company details
Sector
Health Care
Industry (SIC)
Professional Services
Headquarters
WILMINGTON, MA
Fiscal year end
December
CIK
1100682
SIC
8731

Financial performance, year by year

Fiscal 2013–2025 · USD
$-672.87M$636.84M$1.95B$3.26B$4.57B2013201420152016201720182019202020212022202320242025Last 12 moLast 12 monthsLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns Charles River Laboratories — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

581
funds hold it
1 of 35
superinvestors hold it
$5.92B
held by funds, at market
59.8%
of shares held by funds
3
bond issues held by funds

Superinvestors in Charles River Laboratories · what they did last quarter

Bill NygrenINCREASED +4.1%
Harris Associates (Oakmark)
0.7%of 13F portfolio

Share of each manager’s reported 13F portfolio. Change is in shares held, since the previous quarter.

Largest fund holders · Charles River Laboratories’s weight in each

0.23%of fund net assets
VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.02%of fund net assets
Oakmark Select Fund
OAKLX · HARRIS ASSOCIATES INVESTMENT TRUST
4.08%of fund net assets
Allspring Special Mid Cap Value Fund
WFMDX · ALLSPRING FUNDS TRUST
2.45%of fund net assets
VANGUARD 500 INDEX FUND
VOO · VANGUARD INDEX FUNDS
0.02%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Charles River Laboratories’s bonds, as funds hold them

Funds report holding 3 issues of Charles River Laboratories’s debt, $484.81M at market value — what funds hold, not the company’s total debt. Weighted-average coupon 4.00%, maturing 2028 to 2031.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Fund ownership is a subset of institutional 13F ownership — the two describe overlapping populations and must not be added together.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

Put this business in context.

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  • “How do Charles River Laboratories and its peers compare on margins and cash generation over ten years?”
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