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Companies / Healthcare / Equillium, Inc.
EQ

Equillium, Inc.

HealthcarePharmaceutical Preparations
Ticker EQLA JOLLA, CAFiscal year ends DecemberBook value per share $0.54Diluted shares 104.1M

Equillium, Inc. (Nasdaq Capital Market: EQ) is a biotechnology company focused on developing novel therapies to treat severe autoimmune and inflammatory disorders. The company's website is www.equilliumbio.com. From the company’s description.

Fiscal year 2025 · ends 12-31Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-06-30
Sales & profitability
—
0.00%
$-22.40M
−177.6% year over year
Last 12 mo $-18.01M
-78.32%
−36 percentage points
Last 12 mo -32.15%
Cash & financing
$-22.75M
−19.6% year over year
Last 12 mo $-19.97M
$-22.79M
−19.3% year over year
Last 12 mo $-20.09M
—
57.3M
+62.1% year over year
Last 12 mo 104.1M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What Equillium, Inc. does

In the company’s own words

Equillium, Inc. (Nasdaq Capital Market: EQ) is a biotechnology company focused on developing novel therapies to treat severe autoimmune and inflammatory disorders. The company's website is www.equilliumbio.com.

Equillium operates as a clinical-stage biopharmaceutical company with a pipeline centered on two primary product candidates. EQ504 is a potent and selective aryl hydrocarbon receptor modulator designed with a multi-modal, non-immunosuppressive mechanism of action. The company initially intends to develop EQ504 for the treatment of ulcerative colitis and other gastrointestinal diseases, with potential expansion into inflammatory lung diseases. EQ302 is a first-in-class, selective bi-specific inhibitor of IL-15 and IL-21 formulated for oral delivery, being evaluated for celiac disease and other gastrointestinal indications.

The company acquired exclusive worldwide rights to EQ504 through the October 2024 acquisition of Ariagen, Inc., with potential regulatory milestone payments up to $55 million. Equillium obtained rights to EQ302 through its February 2022 acquisition of Bioniz Therapeutics, Inc., with potential regulatory milestone payments up to $5 million related to this asset.

Equillium's intellectual property portfolio comprises two main wings: a portfolio of patents directed to selective aryl hydrocarbon receptor modulators acquired through Ariagen, and a portfolio of composite peptide antagonist patents acquired through Bioniz. The AhR modulator portfolio includes four patent families with issued patents in the United States, Korea, Hong Kong, Japan, India, Mexico, and New Zealand, with expiration dates ranging from 2037 to 2047. The composite peptide portfolio includes four patent families with issued patents across multiple jurisdictions and expected expiration dates from 2032 to 2041.

The company plans to commence a Phase 1 healthy volunteer study for EQ504 in mid-2026, with data expected approximately six months thereafter. Equillium raised approximately $30 million in gross proceeds through a private placement in August 2025 and an additional $35 million in March 2026. The company believes its cash and cash equivalents will be sufficient to fund operating expenses into 2029. Equillium does not own manufacturing facilities and relies on contract manufacturing organizations for all drug substance and drug product needs.

Company details
Sector
Healthcare
Industry
Pharmaceutical Preparations
Headquarters
LA JOLLA, CA
Fiscal year end
December
CIK
1746466
SIC
2834

Financial performance, year by year

Fiscal 2018–2025 · USD
$-72.78M$-41.72M$-10.67M$20.39M$51.45M20182019202020212022202320242025Last 12 moLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns Equillium, Inc. — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

15
funds hold it
0 of 35
superinvestors hold it
$18.91M
held by funds, at market
9.4%
of shares held by funds

Largest fund holders · Equillium, Inc.’s weight in each

1.69%of fund net assets
VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.00%of fund net assets
VANGUARD EXTENDED MARKET INDEX FUND
VXF · VANGUARD INDEX FUNDS
0.00%of fund net assets
Fidelity Extended Market Index Fund
FSMAX · Fidelity Concord Street Trust
0.00%of fund net assets
iShares Micro-Cap ETF
IWC · iShares Trust
0.03%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

Put this business in context.

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