GH

Guardant Health, Inc.

Ticker: GHHealthcareHealth Services
HQ PALO ALTO, CACIK 1576280FY end 12-31Book / share $-1.69Shares 132M
Revenue (FY)
$982.02M+32.88%
TTM $1.18B
Op. margin
-44.53%+15.50%
TTM -39.75%
Net income
$-416.28M+4.61%
TTM $-453.44M
Operating cash
$-184.76M+22.97%
TTM $-185.19M
Free cash flow
$-233.07M+15.23%
TTM $-240.72M
Return on equity
419.18%+106.70%
TTM 203.46%
Debt / equity
-15.14-6.96%
TTM -6.74
Shares outstanding
125.4M+2.14%
TTM 132.1M

The business

Guardant Health, Inc. (NASDAQ: GH) is a leading precision oncology company focused on transforming patient care through advanced blood and tissue-based testing, real-world data analytics, and artificial intelligence. The company's website is www.guardanthealth.com.

Guardant Health operates across three primary business segments: therapy selection, minimal residual disease detection and recurrence monitoring, and early cancer screening. The therapy selection segment includes the Guardant360 CDx test, the first FDA-approved comprehensive liquid biopsy for tumor mutation profiling and companion diagnostic applications across non-small cell lung cancer, colorectal cancer, and breast cancer. The company also offers the Guardant360 Liquid test measuring over 740 genes and the Guardant360 Tissue test incorporating comprehensive multiomics analysis. The minimal residual disease segment features the Guardant Reveal test for detecting residual and recurring disease in early-stage cancer patients and monitoring therapy response in advanced-stage patients. The screening segment centers on the Shield blood test, the first FDA-approved blood test for primary colorectal cancer screening that meets Medicare coverage requirements.

Beyond clinical diagnostics, Guardant Health serves biopharmaceutical companies through its GuardantINFINITY and GuardantOMNI tests for clinical research and therapy development, along with the GuardantINFORM platform providing genomic and epigenetic insights into disease progression and treatment impact. The company's proprietary Smart Platform leverages genomic, epigenomic, and RNA-based data to deliver multiomic insights scalable from research to clinical applications.

Guardant Health operates clinical laboratories in Redwood City and Palo Alto, California, and Long Island City, New York, with research and development centers across multiple California locations. The company maintains a targeted sales organization focused on oncologists, cancer centers, and primary care physicians in the United States, while expanding internationally through partnerships with cancer centers, research organizations, and laboratory companies in Europe, Asia, the Middle East, and Africa. The company has established partnerships with leading institutions including Vall D'Hebron Institute of Oncology in Spain, The Royal Marsden NHS Foundation Trust in the United Kingdom, Policlinico Gemelli in Italy, and Adicon Holdings in China to advance global commercialization of its testing platform.

Sector
Healthcare
Industry
Health Services
HQ
PALO ALTO, CA
FY end
12-31
CIK
1576280
SIC
8071
Financial performance · annual
20182025
$-838.36M$-287.05M$264.26M$815.57M$1.37B20182019202020212022202320242025TTMTTMTTM

Ownership

Who holds Guardant Health, Inc. — across funds, superinvestors and bonds · N-PORT 2026Q2 · 13F 2026-06-30

561
funds hold it
1 of 35
superinvestors hold it
$8.12B
fund-held value
46.0%
of shares held by funds
3
bond issues held by funds

Top fund holders

Fund% of fundValue
VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.03%$600.07M
VANGUARD SMALL-CAP INDEX FUND
VB · VANGUARD INDEX FUNDS
0.23%$433.37M
T. Rowe Price New Horizons Fund, Inc.
PRNHX · T. ROWE PRICE NEW HORIZONS FUND, INC.
1.81%$266.83M
Franklin Dynatech Fund
FKDNX · Franklin Custodian Funds
0.87%$262.55M
FULLERTHALER BEHAVIORAL SMALL-CAP GROWTH
FTXNX · Capitol Series Trust
4.20%$259.48M

Superinvestors in Guardant Health, Inc.

Polen CapitalDECREASED -1.0%
Polen Capital Management
<0.1%

Share of each manager's reported 13F portfolio.

Bonds held by funds

Funds report holding 3 issues of Guardant Health, Inc.'s debt, $263.19M at fund-held market value — what funds hold, not the company's debt outstanding. Weighted-average coupon 1.25%, maturing 20272033.

IssueCouponMaturesFundsFund-held
Guardant Health Inc0.000%None2033-05-1534$170.05M
GH 1.25 02/15/311.250%2031-02-1521$55.88M
Guardant Health Inc0.000%None2027-11-1513$37.26M

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Fund ownership is a subset of institutional 13F ownership — the two describe overlapping populations and must not be added together.

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15 years of Guardant Health, Inc.'s financials

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