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Companies / Health Care / Omeros Corporation
OMER

Omeros Corporation

Health CarePharmaceutical Preparations
Ticker OMERSEATTLE, WAFiscal year ends DecemberBook value per share $-0.57Diluted shares 89.9M

Omeros Corporation (Nasdaq: OMER) is a commercial-stage biotechnology company that discovers and develops protein and small-molecule therapeutics, with programs focused on complement-mediated diseases, cancer, and addictive or compulsive disorders. Its commercial product, YARTEMLEA, is an antibody that inhibits MASP-2… From the company’s description.

In fiscal 2025, Omeros Corporation reported a net loss of $3.35M. Operations used $116.09M in cash.

Fiscal year 2025 · ends 12-31Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-06-30
Sales & profitability
—
0.00%FY2025
$-3.35MFY2025
+97.9% year over year
Last 12 mo $124.83M
2.76%FY2025
−83.1 percentage points
Last 12 mo -243.09%
Cash & financing
$-116.09MFY2025
+22.0% year over year
Last 12 mo $-68.67M
$-116.16MFY2025
+22.0% year over year
Last 12 mo $-68.73M
-0.56FY2025
Was -1.03× a year earlier
Last 12 mo -0.82
67.0MFY2025
Last 12 mo 89.9M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What Omeros Corporation does

In the company’s own words

Omeros Corporation (Nasdaq: OMER) is a commercial-stage biotechnology company that discovers and develops protein and small-molecule therapeutics, with programs focused on complement-mediated diseases, cancer, and addictive or compulsive disorders. Its commercial product, YARTEMLEA, is an antibody that inhibits MASP-2 in the lectin pathway of complement and is approved in the United States to treat hematopoietic stem cell transplant-associated thrombotic microangiopathy in adults and children aged two years and older. U.S. sales began in January 2026, with commercialization focused on transplant centers. Omeros also develops narsoplimab for other potential uses, a long-acting MASP-2 antibody, a PDE7 inhibitor for cocaine use disorder and movement disorders, an oncology candidate for acute myeloid leukemia, and targeted complement-activating therapies for infectious diseases. In 2025, it transferred exclusive global development and commercialization rights to its lead MASP-3 antibody, zaltenibart, to Novo Nordisk, while retaining rights to related small-molecule programs. YARTEMLEA and YARTEMLEAssist are its principal commercial brands.

Company details
Sector
Health Care
Industry (SIC)
Pharmaceutical Preparations
Headquarters
SEATTLE, WA
Fiscal year end
December
CIK
1285819
SIC
2834

Financial performance, year by year

Fiscal 2011–2025 · USD
$-191.92M$-86.61M$18.71M$124.03M$229.34M201120122013201420152016201720182019202020212022202320242025Last 12 moLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns Omeros Corporation — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

133
funds hold it
0 of 35
superinvestors hold it
$118.59M
held by funds, at market
15.8%
of shares held by funds

Largest fund holders · Omeros Corporation’s weight in each

VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.00%of fund net assets
iShares Russell 2000 ETF
IWM · iShares Trust
0.02%of fund net assets
Fidelity Small Cap Index Fund
FSSNX · Fidelity Salem Street Trust
—of fund net assets
VANGUARD EXTENDED MARKET INDEX FUND
VXF · VANGUARD INDEX FUNDS
0.01%of fund net assets
1.42%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

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