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Companies / Healthcare / Seres Therapeutics, Inc.
MCRB

Seres Therapeutics, Inc.

HealthcarePharmaceutical Preparations
Ticker MCRBCAMBRIDGE, MAFiscal year ends DecemberBook value per share $3.58Diluted shares 9.6M

Seres Therapeutics, Inc. (NASDAQ: MCRB) is a clinical-stage biopharmaceutical company focused on discovering and developing novel live biotherapeutic products to improve patient outcomes in medically vulnerable populations. The company's website is www.seresrx.com. From the company’s description.

Fiscal year 2025 · ends 12-31Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-06-30
Sales & profitability
$0.79M
-11910.14%
$5.70M
+4088.2% year over year
Last 12 mo $-22.46M
12.88%
+11.9 percentage points
Last 12 mo -65.05%
Cash & financing
$1.12M
+100.8% year over year
Last 12 mo $-51.26M
$0.86M
+100.6% year over year
Last 12 mo $-51.30M
—
8.9M
+14.2% year over year
Last 12 mo 9.6M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What Seres Therapeutics, Inc. does

In the company’s own words

Seres Therapeutics, Inc. (NASDAQ: MCRB) is a clinical-stage biopharmaceutical company focused on discovering and developing novel live biotherapeutic products to improve patient outcomes in medically vulnerable populations. The company's website is www.seresrx.com.

Seres pioneered the development of VOWST, the first FDA-approved orally administered microbiome biotherapeutic, which was sold to Nestlé Health Science in September 2024. The company has established field-leading capabilities and platforms powered by proprietary human datasets to advance a portfolio of live biotherapeutic candidates targeting diseases associated with the mucosal barrier-immune interface.

The company's pipeline consists of three primary programs. SER-155, the most advanced candidate, is designed to decolonize gastrointestinal pathogens, improve epithelial barrier integrity, and prevent bacterial bloodstream infections in patients undergoing allogeneic hematopoietic stem cell transplantation. In December 2024, the FDA granted Breakthrough Therapy designation to SER-155 for reducing bloodstream infections in allo-HSCT patients. SER-603 targets inflammatory bowel disease, including ulcerative colitis and Crohn's disease, through non-immunosuppressive mechanisms. SER-147 is designed to prevent bacterial infections in patients with chronic liver disease.

Seres has developed the MbTx Platform, a proprietary reverse translational discovery and development system that integrates high-resolution human clinical data analysis, preclinical screening using human cell-based assays, and a functionally characterized strain library of bacterial isolates. The company maintains manufacturing capabilities specifically designed for live biotherapeutics production under current Good Manufacturing Practices standards at its Cambridge, Massachusetts facility.

The company was founded by Flagship Pioneering and has assembled experienced management with core capabilities in live biotherapeutics, drug development, regulatory approval, manufacturing, and commercialization. Seres has established long-standing collaborations with leading academic medical centers, including Memorial Sloan Kettering Cancer Center, to advance clinical development and generate translational data supporting its therapeutic approach across infectious disease and inflammatory and immune disease indications.

Company details
Sector
Healthcare
Industry
Pharmaceutical Preparations
Headquarters
CAMBRIDGE, MA
Fiscal year end
December
CIK
1609809
SIC
2834

Financial performance, year by year

Fiscal 2015–2025 · USD
$-289.67M$-171.14M$-52.62M$65.91M$184.44M20152016201720182019202020212022202320242025Last 12 moLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns Seres Therapeutics, Inc. — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

24
funds hold it
0 of 35
superinvestors hold it
$3.83M
held by funds, at market
5.0%
of shares held by funds

Largest fund holders · Seres Therapeutics, Inc.’s weight in each

VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.00%of fund net assets
VANGUARD EXTENDED MARKET INDEX FUND
VXF · VANGUARD INDEX FUNDS
0.00%of fund net assets
Avantis U.S. Small Cap Value ETF
AVUV · American Century ETF Trust
0.00%of fund net assets
Schwab U.S. Small-Cap ETF
SCHA · SCHWAB STRATEGIC TRUST
0.00%of fund net assets
iShares Micro-Cap ETF
IWC · iShares Trust
0.01%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

Put this business in context.

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