10x Insights
Loading account…
Companies / Health Care / Syndax Pharmaceuticals Inc
SNDX

Syndax Pharmaceuticals Inc

Health CarePharmaceutical Preparations
Ticker SNDXNEW YORK, NYFiscal year ends DecemberBook value per share $-0.19Diluted shares 89.0M

Syndax Pharmaceuticals, Inc. (Nasdaq: SNDX) is a commercial-stage biopharmaceutical company developing and commercializing cancer therapies. Its two FDA-approved medicines are Revuforj (revumenib), an oral menin inhibitor for certain forms of relapsed or refractory acute leukemia, and Niktimvo (axatilimab-csfr), a… From the company’s description.

Over the twelve months to Sep 30, 2026, Syndax Pharmaceuticals Inc reported revenue of $289.68M, up 160.3% from a year earlier, and a net loss of $209.48M. Its operating margin was −61.7%, and operations used $177.36M in cash. In fiscal 2025, it reported revenue of $172.35M, up 627.8% from fiscal 2024, and a net loss of $285.42M.

Fiscal year 2025 · ends 12-31Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-09-30
Sales & profitability
$172.35MFY2025
+627.8% year over year
Last 12 mo $289.68M
-158.45%FY2025
+1276 percentage points
Last 12 mo -61.67%
$-285.42MFY2025
+10.5% year over year
Last 12 mo $-209.48M
-441.62%FY2025
−331 percentage points
Last 12 mo 1219.34%
Cash & financing
$-322.98MFY2025
−17.5% year over year
Last 12 mo $-177.36M
$-323.17MFY2025
−17.6% year over year
Last 12 mo $-177.46M
—
Was 1.19× a year earlier
Last 12 mo -14.21
86.6MFY2025
+1.2% year over year
Last 12 mo 89.0M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What Syndax Pharmaceuticals Inc does

In the company’s own words

Syndax Pharmaceuticals, Inc. (Nasdaq: SNDX) is a commercial-stage biopharmaceutical company developing and commercializing cancer therapies. Its two FDA-approved medicines are Revuforj (revumenib), an oral menin inhibitor for certain forms of relapsed or refractory acute leukemia, and Niktimvo (axatilimab-csfr), a CSF-1R-blocking antibody for chronic graft-versus-host disease after at least two prior systemic therapies. Syndax leads U.S. commercialization and development of Revuforj and co-commercializes Niktimvo in the United States with Incyte, which leads its global commercialization. Development programs include studying revumenib in combinations for acute leukemia and axatilimab in earlier-line chronic graft-versus-host disease and idiopathic pulmonary fibrosis. The company also holds a license for entinostat, a deprioritized cancer drug candidate approved for marketing in China. It licenses its medicines from other companies and relies on contract manufacturers and partners for product supply. Syndax reported 2025 revenue of $[amount not provided]. Its website is [URL not provided].

Company details
Sector
Health Care
Industry (SIC)
Pharmaceutical Preparations
Headquarters
NEW YORK, NY
Fiscal year end
December
CIK
1395937
SIC
2834

Financial performance, year by year

Fiscal 2016–2025 · USD
$-379.60M$-197.07M$-14.54M$167.99M$350.52M2016201720182019202020212022202320242025Last 12 moLast 12 monthsLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns Syndax Pharmaceuticals Inc — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

197
funds hold it
0 of 35
superinvestors hold it
$542.93M
held by funds, at market
28.1%
of shares held by funds
1
bond issues held by funds

Largest fund holders · Syndax Pharmaceuticals Inc’s weight in each

0.72%of fund net assets
VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.00%of fund net assets
iShares Russell 2000 ETF
IWM · iShares Trust
0.06%of fund net assets
Hood River Small-Cap Growth Fund
HRSMX · Manager Directed Portfolios
0.40%of fund net assets
VANGUARD EXTENDED MARKET INDEX FUND
VXF · VANGUARD INDEX FUNDS
0.02%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Syndax Pharmaceuticals Inc’s bonds, as funds hold them

Funds report holding 1 issues of Syndax Pharmaceuticals Inc’s debt, $0.18M at market value — what funds hold, not the company’s total debt. Weighted-average coupon 2.25%, maturing 2031 to 2031.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

Put this business in context.

Compare this company with peers, find it in your funds and follow its financial history with your connected AI:

  • “How do Syndax Pharmaceuticals Inc and its peers compare on margins and cash generation over ten years?”
  • “Where did five years of Syndax Pharmaceuticals Inc's earnings go — cash, debt, buybacks, reinvestment?”
  • “What changed in Syndax Pharmaceuticals Inc's last four quarterly filings that the numbers alone won't show?”
See how it works →All research tools with a subscription. Use your own AI account.