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Companies / Health Care / BridgeBio Oncology Therapeutics, Inc.
BBOT

BridgeBio Oncology Therapeutics, Inc.

Health CarePharmaceutical Preparations
Ticker BBOTSOUTH SAN FRANCISCO, CAFiscal year ends DecemberBook value per share $4.04Diluted shares 80.1M

BridgeBio Oncology Therapeutics, Inc. (Nasdaq: BBOT) is a clinical-stage biotechnology company developing oral small-molecule therapies for cancers driven by RAS and PI3Kα oncogenes. Its pipeline includes BBO-8520, a dual ON/OFF KRAS G12C inhibitor; BBO-11818, a dual ON/OFF pan-KRAS inhibitor; and BBO-10203, which… From the company’s description.

In fiscal 2025, BridgeBio Oncology Therapeutics, Inc. reported a net loss of $134.04M. Operations used $113.89M in cash.

Fiscal year 2025 · ends 12-31Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-06-30
Sales & profitability
—
0.00%FY2025
$-134.04MFY2025
−1863.9% year over year
Last 12 mo $-233.03M
-32.61%FY2025
+171 percentage points
Last 12 mo -72.12%
Cash & financing
$-113.89MFY2025
−14811.1% year over year
Last 12 mo $-193.14M
$-114.50MFY2025
−14890.4% year over year
Last 12 mo $-193.14M
0.00FY2025
Was 0.00× a year earlier
31.1MFY2025
+87.2% year over year
Last 12 mo 80.1M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What BridgeBio Oncology Therapeutics, Inc. does

In the company’s own words

BridgeBio Oncology Therapeutics, Inc. (Nasdaq: BBOT) is a clinical-stage biotechnology company developing oral small-molecule therapies for cancers driven by RAS and PI3Kα oncogenes. Its pipeline includes BBO-8520, a dual ON/OFF KRAS G12C inhibitor; BBO-11818, a dual ON/OFF pan-KRAS inhibitor; and BBO-10203, which blocks RAS-mediated activation of PI3Kα. The company is evaluating these candidates as single agents and in combinations for cancers including lung, breast, colorectal and pancreatic cancer. Its Phase 1 programs include studies in patients with KRAS-mutant solid tumors and breast and colorectal cancers. The pipeline also supports planned combinations targeting both MAPK and PI3Kα signaling pathways. BridgeBio Oncology Therapeutics was formed following an August 2025 business combination between Helix Acquisition Corp. II and TheRas, Inc., which operated as BridgeBio Oncology Therapeutics; Helix adopted the BridgeBio Oncology Therapeutics name upon completion. The company reports no commercial product revenue, and its business is focused on drug research and clinical development. Its website is https://bbotx.com/.

Company details
Sector
Health Care
Industry (SIC)
Pharmaceutical Preparations
Headquarters
SOUTH SAN FRANCISCO, CA
Fiscal year end
December
CIK
1869105
SIC
2834

Financial performance, year by year

Fiscal 2024–2025 · USD
$-257.10M$-184.91M$-112.72M$-40.53M$31.66M20242025Last 12 moLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns BridgeBio Oncology Therapeutics, Inc. — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

41
funds hold it
0 of 35
superinvestors hold it
$48.85M
held by funds, at market
7.6%
of shares held by funds

Largest fund holders · BridgeBio Oncology Therapeutics, Inc.’s weight in each

VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.00%of fund net assets
0.06%of fund net assets
—of fund net assets
VANGUARD EXTENDED MARKET INDEX FUND
VXF · VANGUARD INDEX FUNDS
0.00%of fund net assets
iShares Biotechnology ETF
IBB · iShares Trust
0.03%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Could not be determined for this company: bond issues.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

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  • “How do BridgeBio Oncology Therapeutics, Inc. and its peers compare on margins and cash generation over ten years?”
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