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Companies / Health Care / Revolution Medicines, Inc.
RVMD

Revolution Medicines, Inc.

Health CareBiological Products
Ticker RVMDREDWOOD CITY, CAFiscal year ends DecemberBook value per share $12.74Diluted shares 204.5M

Revolution Medicines, Inc. (NASDAQ: RVMD) is a clinical-stage precision oncology company developing novel targeted therapies for RAS-addicted cancers. The company's website is located at ir.revmed.com. Revolution Medicines possesses sophisticated structure-based drug discovery capabilities built upon deep chemical… From the company’s description.

Fiscal year 2025 · ends 12-31Changes are against fiscal 2024The amber dot is the latest twelve months, to 2026-06-30
Sales & profitability
$0.00MFY2025
0.00%FY2025
$-1.13BFY2025
−88.5% year over year
Last 12 mo $-1.77B
-69.35%FY2025
−42.9 percentage points
Last 12 mo -67.85%
Cash & financing
$-897.74MFY2025
−61.0% year over year
Last 12 mo $-1.22B
$-913.73MFY2025
−60.9% year over year
Last 12 mo $-1.23B
—
Last 12 mo 0.19
190.1MFY2025
+13.3% year over year
Last 12 mo 204.5M

Margins and return on equity change in ; everything else in percent. Fewer shares and less debt are shown plainly, not as bad news — it depends what you make of buybacks. Dotted labels explain each measure. is shown separately from the annual figures.

What Revolution Medicines, Inc. does

In the company’s own words

Revolution Medicines, Inc. (NASDAQ: RVMD) is a clinical-stage precision oncology company developing novel targeted therapies for RAS-addicted cancers. The company's website is located at ir.revmed.com. Revolution Medicines possesses sophisticated structure-based drug discovery capabilities built upon deep chemical biology and cancer pharmacology expertise and proprietary technologies that enable the creation of small molecules tailored to unconventional binding sites on cancer targets.

The company's core innovation engine centers on its proprietary tri-complex technology platform designed to inhibit RAS(ON), the active GTP-bound form of RAS proteins. This differentiated mechanism of action represents the first class of RAS inhibitors in clinical development to specifically target the activated form of oncogenic RAS, offering potential improvements over first-generation RAS(OFF) inhibitors that interact exclusively with the inactive form. Revolution Medicines' research and development pipeline comprises inhibitors designed as both monotherapy and in combination with other RAS(ON) inhibitors and therapeutic agents.

The company's lead program, daraxonrasib, is a RAS(ON) multi-selective inhibitor designed to inhibit multiple oncogenic RAS variants at the G12, G13, and Q61 hotspot positions. Additional clinical-stage candidates include zoldonrasib, a G12D-selective inhibitor; elironrasib, a G12C-selective inhibitor; and RMC-5127, a G12V-selective inhibitor. The company is also developing a new class of RAS(ON) inhibitors designed to overcome RAS-driven drug resistance.

Revolution Medicines is advancing multiple global randomized Phase 3 registrational studies across pancreatic ductal adenocarcinoma, non-small cell lung cancer, and colorectal cancer. The company has established clinical collaborations with major pharmaceutical companies including Bristol Myers Squibb, Amgen, Summit Therapeutics, and Tango Therapeutics to evaluate its RAS(ON) inhibitors in combination with complementary therapeutic agents. Revolution Medicines relies on contract development and manufacturing organizations for all manufacturing activities and intends to retain significant development and commercialization rights to its product candidates, with plans to commercialize initially in the United States followed by key international markets.

Company details
Sector
Health Care
Industry (SIC)
Biological Products
Headquarters
REDWOOD CITY, CA
Fiscal year end
December
CIK
1628171
SIC
2836

Financial performance, year by year

Fiscal 2020–2025 · USD
$-1.95B$-1.41B$-862.65M$-319.27M$224.11M202020212022202320242025Last 12 moLast 12 months

The full income statement, balance sheet and cash flow for each of these years — every figure traceable to its filing — is on the Financials tab with a free account.

Ownership

Who owns Revolution Medicines, Inc. — and what changed

Funds as of 2026Q2 · superinvestors as of 2026-06-30

497
funds hold it
1 of 35
superinvestors hold it
$10.28B
held by funds, at market
27.5%
of shares held by funds
1
bond issues held by funds

Superinvestors in Revolution Medicines, Inc. · what they did last quarter

Stanley DruckenmillerINCREASED +26.5%
Duquesne Family Office
1.7%of 13F portfolio

Share of each manager’s reported 13F portfolio. Change is in shares held, since the previous quarter.

Largest fund holders · Revolution Medicines, Inc.’s weight in each

VANGUARD TOTAL STOCK MARKET INDEX FUND
VTI · VANGUARD INDEX FUNDS
0.05%of fund net assets
VANGUARD SMALL-CAP INDEX FUND
VB · VANGUARD INDEX FUNDS
0.46%of fund net assets
VANGUARD SMALL-CAP GROWTH INDEX FUND
VBK · VANGUARD INDEX FUNDS
1.06%of fund net assets
VANGUARD EXTENDED MARKET INDEX FUND
VXF · VANGUARD INDEX FUNDS
0.44%of fund net assets
Fidelity Growth Company Fund
FDGRX · Fidelity Mt. Vernon Street Trust
0.39%of fund net assets

Fund ownership is a floor, not a census — pensions, insurers and people holding shares directly are not visible here.

Revolution Medicines, Inc.’s bonds, as funds hold them

Funds report holding 1 issues of Revolution Medicines, Inc.’s debt, $137.63M at market value — what funds hold, not the company’s total debt. Weighted-average coupon 0.50%, maturing 2033 to 2033.

Fund ownership counts N-PORT filers only, so it is a floor rather than a census — pensions, insurers and direct holders are not visible here, and the remainder is not “held by individuals”.

Fund ownership is a subset of institutional 13F ownership — the two describe overlapping populations and must not be added together.

Every fund and institutional holder, quarter by quarter, is on the Ownership tab with a free account.

Connected research

Put this business in context.

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